Description

Tauro-α-Muricholic Acid is a conjugated bile acid derivative, specifically the taurine amide of α-muricholic acid. This compound is of significant interest in biochemical and pharmaceutical research due to its role as a specific and potent endogenous agonist for the Takeda G protein-coupled receptor 5 (TGR5). It is primarily utilized by research institutions and pharmaceutical companies engaged in metabolic disease studies, liver function research, and the development of novel therapeutics targeting bile acid signaling pathways.

Application

• Biochemical Research: Used as a high-purity reference standard and reagent for studying bile acid metabolism and enterohepatic circulation.
• Pharmacology & Drug Discovery: Serves as a critical tool compound for activating and studying the TGR5 receptor, a target for metabolic disorders like diabetes, obesity, and non-alcoholic steatohepatitis (NASH).
• Cell Signaling Studies: Employed in in vitro and in vivo models to investigate the anti-inflammatory and metabolic effects of TGR5 receptor activation.
• Analytical Standard: Essential for the development and validation of analytical methods (HPLC, LC-MS) for the quantification of bile acids in biological samples.
• Academic Research: Fundamental for university and institutional research into gastroenterology, endocrinology, and molecular biology.

Basic Information

Product Name	Tauro-α-Muricholic Acid
CAS No.	25613-05-2
Molecular Formula	C₂₆H₄₅NO₇S
Molecular Weight	515.70 g/mol
Synonyms	α-Muricholyltaurine; Tauroursodeoxycholic Acid 6β-isomer; 3α,6β,7α-Trihydroxy-5β-cholan-24-oyltaurine; T-α-MCA; Tauro-α-muricholate; Taurine conjugate of α-muricholic acid; 5β-Cholan-24-oic acid, 3,6,7-trihydroxy-, (3α,5β,6β,7α)-, compd. with 2-aminoethanesulfonic acid (1:1)
EINECS	Contact for details

Quality Control

Our Tauro-α-Muricholic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and MS, to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability, purity, and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the sealed vial to warm to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.5%
Specific Rotation	Contact for details
Solubility	Soluble in methanol, ethanol; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.