Description

L-Histidine Hydroxamate is a specialized derivative of the essential amino acid L-Histidine, where the carboxyl group is replaced by a hydroxamic acid functional group. This modification imparts unique metal-chelating properties, making it a valuable intermediate and research chemical for advanced biochemical and pharmaceutical applications. It is primarily utilized by research institutions, pharmaceutical developers, and fine chemical manufacturers involved in metalloenzyme studies, chelation therapy research, and the synthesis of novel bioactive compounds.

Application

• Biochemical Research: As a potent and specific chelating agent for studying metalloenzymes, particularly those containing iron, nickel, or zinc.
• Pharmaceutical Intermediates: A key building block in the research and development of novel therapeutic agents, including protease inhibitors and anti-inflammatory drugs.
• Chelation Therapy Studies: Investigated for its potential in binding and facilitating the removal of excess heavy metals from biological systems.
• Enzyme Inhibition: Used in mechanistic studies to inhibit specific enzymes like urease and matrix metalloproteinases (MMPs) due to its metal-binding capability.
• Analytical Chemistry: Employed as a reagent for the spectrophotometric determination and separation of various metal ions.
• Fine Chemical Synthesis: Serves as a precursor for synthesizing more complex hydroxamate-based molecules with tailored biological activities.

Basic Information

Item	Detail
Product Name	L-Histidine Hydroxamate
CAS No.	25486-00-4
Molecular Formula	C6H10N4O2
Molecular Weight	170.17 g/mol
Synonyms	L-Histidinehydroxamic acid; (2S)-2-Amino-3-(1H-imidazol-4-yl)propanehydroxamic acid; Histidine hydroxamic acid; L-Histidine, hydroxamic acid; Histidinehydroxamate; N-Hydroxy-L-histidinamide; 4-Imidazolepropionohydroxamic acid, L-α-amino-
EINECS	Contact for details

Quality Control

Our L-Histidine Hydroxamate is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation	[α]20/D: Specific range available on COA
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.2%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.