Description

(6A,11B,16A)-6,9-Difluoro-11-Hydroxy-16-Methylandrosta-1,4-Diene-3,17-Dione is a high-purity, fluorinated steroid derivative with significant biological activity. This compound serves as a critical pharmaceutical intermediate in the synthesis of advanced corticosteroid and anti-inflammatory agents. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers for the development of novel therapeutic compounds.

Application

• Key Intermediate in Corticosteroid Synthesis: Used in the production of potent glucocorticoid receptor agonists.
• Pharmaceutical Research & Development: Serves as a building block for novel anti-inflammatory and immunosuppressive drug candidates.
• Fine Chemical Manufacturing: Employed in multi-step synthetic routes for specialized steroid-based APIs (Active Pharmaceutical Ingredients).
• Biochemical Research: Utilized in studies investigating steroid hormone receptor binding and modulation.
• Process Development & Scale-up: Critical for optimizing synthetic pathways from laboratory to pilot and commercial scale.

Basic Information

Item	Detail
Product Name	(6A,11B,16A)-6,9-Difluoro-11-Hydroxy-16-Methylandrosta-1,4-Diene-3,17-Dione
CAS No.	25256-97-7
Molecular Formula	C20H24F2O3
Molecular Weight	350.40 g/mol
Synonyms	6α,9α-Difluoro-11β-hydroxy-16α-methylandrosta-1,4-diene-3,17-dione; 6α,9α-Difluoro-11β,17α,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione related compound; 6α,9α-Difluoro-16α-methylprednisolone intermediate; Difluoromethylprednisolone intermediate; Fluorinated steroid intermediate; 25256-97-7; 6,9-Difluoro-11-Hydroxy-16-Methylandrostadienedione
EINECS	Contact for details

Quality Control

Our (6A,11B,16A)-6,9-Difluoro-11-Hydroxy-16-Methylandrosta-1,4-Diene-3,17-Dione is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC and NMR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your GMP-compliant processes and regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.