Description

Uridine Diphosphate n-Acetyl-D-Mannosaminuronic Acid is a crucial nucleotide-activated sugar donor, essential for the biosynthesis of complex polysaccharides and glycoconjugates. Its primary value lies in enabling precise enzymatic glycosylation reactions, making it indispensable for research and development in glycobiology and synthetic biochemistry. This high-purity biochemical is primarily required by pharmaceutical researchers, biotechnology companies, and academic institutions focused on carbohydrate synthesis, vaccine development, and the study of bacterial cell wall assembly.

Application

• Enzymatic Synthesis of Glycoconjugates: Acts as a key substrate for glycosyltransferases in the synthesis of oligosaccharides and glycoproteins.
• Bacterial Cell Wall Research: Critical for studying and synthesizing components of bacterial capsular polysaccharides and O-antigens.
• Biochemical Assay Development: Used as a standard or reagent in high-throughput screening assays for glycosyltransferase activity and inhibitor discovery.
• Glycoengineering: Enables the chemoenzymatic modification of therapeutic proteins, antibodies, and other biologics to optimize their pharmacokinetic properties.
• Academic Research: Fundamental tool for investigating carbohydrate metabolism, enzyme mechanisms, and structure-function relationships in glycobiology.
• Vaccine Antigen Production: Utilized in the enzymatic synthesis of carbohydrate-based antigens for conjugate vaccine candidates.

Basic Information

Product Name	Uridine Diphosphate n-Acetyl-D-Mannosaminuronic Acid
CAS No.	25174-34-9
Molecular Formula	C17H25N3O18P2
Molecular Weight	645.33 g/mol
Synonyms	UDP-N-Acetyl-D-mannosaminuronic acid; UDP-ManNAcA; Uridine 5'-(trihydrogen diphosphate), P'→5'-ester with 2-(acetylamino)-2-deoxy-D-mannuronic acid; UDP-α-D-ManNAcA; Uridine diphosphate N-acetylmannosaminuronic acid; 2-Acetamido-2-deoxy-D-mannuronic acid UDP ester
EINECS	Contact for details

Quality Control

Our Uridine Diphosphate n-Acetyl-D-Mannosaminuronic Acid is manufactured under stringent quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the exacting standards required for sensitive biochemical applications. Certificates of Analysis (COA) with full chromatographic data are provided to guarantee traceability, consistency, and reliability for your research and development workflows.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 5.0 %
Biological Activity	Functional as a glycosyl donor in standard enzymatic assays

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.