Description

Clobetasone 17 Propionate is a synthetic corticosteroid ester, a key pharmaceutical intermediate in the synthesis of potent topical anti-inflammatory agents. Its primary commercial value lies in its role as a precursor for the manufacture of advanced dermatological corticosteroids, such as Clobetasol Propionate, which are critical for treating severe skin conditions. This high-purity intermediate is essential for pharmaceutical manufacturers and R&D facilities focused on developing and producing steroid-based therapeutics.

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the synthesis of the active pharmaceutical ingredient (API) Clobetasol Propionate.
• Topical Corticosteroid Production: Manufacture of high-potency creams, ointments, and lotions for treating psoriasis, eczema, and dermatitis.
• Research & Development: Used in medicinal chemistry research for developing new steroid derivatives and studying structure-activity relationships (SAR).
• Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method development in pharmaceutical labs.
• Veterinary Pharmaceuticals: Potential use in formulating anti-inflammatory treatments for animal skin conditions.

Basic Information

Product Name	Clobetasone 17 Propionate
CAS No.	25122-56-9
Molecular Formula	C25H31ClFO5
Molecular Weight	465.97 g/mol
Synonyms	Clobetasone 17-Propionate; 21-Chloro-9-fluoro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-propionate; 21-Chloro-9-fluoro-11β,17-dihydroxy-16β-methyl-1,4-pregnadiene-3,20-dione 17-propionate; Clobetasone Propionate; (11β,16β)-21-Chloro-9-fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione 17-propionate
EINECS	Contact for details

Quality Control

Our Clobetasone 17 Propionate is manufactured under strict quality management systems. We provide material that meets high-purity standards suitable for pharmaceutical synthesis. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We can support compliance with cGMP, ICH Q7 guidelines, and relevant pharmacopoeial standards upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Unknown Impurity	≤0.5%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.