Description

Pregna-1,4-Diene-3,20-Dione,11β,16α,17α,21-Tetrahydroxy-1,4-Pregnadiene-3,20-Dione 16,17-Acetonide 21-Acetate is a high-purity synthetic steroid derivative, specifically a protected form of a corticosteroid intermediate. This compound is critically important as a key building block in the multi-step synthesis of potent anti-inflammatory and immunosuppressive pharmaceutical agents. It is primarily needed by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of advanced steroid-based therapeutics.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of advanced corticosteroid drugs, including certain anti-inflammatory and immunosuppressive medications.
• Research & Development: Used in academic and industrial laboratories for studying steroid chemistry, metabolic pathways, and developing new therapeutic entities.
• Process Chemistry: Serves as a standardized starting material or intermediate in optimizing and scaling up GMP-compliant manufacturing processes for active pharmaceutical ingredients (APIs).
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	Pregna-1,4-Diene-3,20-Dione,11β,16α,17α,21-Tetrahydroxy-1,4-Pregnadiene-3,20-Dione 16,17-Acetonide 21-Acetate
CAS No.	25092-25-5
Molecular Formula	C₂₆H₃₄O₈
Molecular Weight	474.55 g/mol
Synonyms	Prednisolone 16,17-Acetonide 21-Acetate; 11β,16α,17α,21-Tetrahydroxy-1,4-pregnadiene-3,20-dione 16,17-Acetonide 21-Acetate; 16α,17α-Isopropylidenedioxy-11β,21-dihydroxypregna-1,4-diene-3,20-dione 21-Acetate; Prednisolone Acetonide 21-Acetate; 9α-Fluoro-16α-methylprednisolone 16,17-acetonide 21-acetate derivative; (11β,16α)-11,21-Dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-pregna-1,4-diene-3,20-dione 21-acetate
EINECS	Contact for details

Quality Control

Our Pregna-1,4-Diene-3,20-Dione,11β,16α,17α,21-Tetrahydroxy-1,4-Pregnadiene-3,20-Dione 16,17-Acetonide 21-Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and identity, meeting the stringent requirements for pharmaceutical intermediate applications. Comprehensive Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.