Description

Phorbol 12,13-Diacetate is a biologically active phorbol ester derivative, a key compound in biochemical and pharmacological research. It serves as a potent activator of protein kinase C (PKC), making it an invaluable tool for studying signal transduction pathways, cellular proliferation, and tumor promotion mechanisms. This high-purity reference standard is essential for researchers and quality control laboratories in the pharmaceutical, biotechnology, and academic sectors.

Application

• Biochemical Research: As a potent and specific activator of Protein Kinase C (PKC) isoforms for studying intracellular signaling cascades.
• Pharmacological Studies: Used in cancer research to investigate tumor promotion mechanisms and cell proliferation pathways.
• Reference Standard: Serves as a high-purity analytical standard for the identification and quantification of phorbol esters in quality control and method development.
• Cell Biology: A critical tool for inducing cellular responses in models of inflammation, immune response, and differentiation.
• Toxicology: Employed in safety assessments and studies of skin irritancy and tumorigenesis.
• Drug Discovery: Used in screening assays to identify novel PKC inhibitors or modulators for therapeutic development.

Basic Information

Product Name	Phorbol 12,13-Diacetate
CAS No.	24928-15-2
Molecular Formula	C28H38O8
Molecular Weight	502.60 g/mol
Synonyms	12-O-Tetradecanoylphorbol-13-acetate (TPA) analog; Phorbol Diacetate; 4,9,12-beta,13-alpha,20-Pentahydroxytiglia-1,6-dien-3-one 12,13-diacetate; 12-Deoxyphorbol 13-acetate 12-acetate; NSC 268492; 1,6-Dideoxy-1,6-diphthalimido-D-mannitol diacetate (related compound search term); Phorbol-12,13-diacetate
EINECS	Contact for details

Quality Control

Our Phorbol 12,13-Diacetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity confirmation and identity verification by spectroscopic methods (IR, NMR), to ensure it meets the high standards required for research applications. A Certificate of Analysis (COA) detailing purity, identity, and specific test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.