Description

Nicotinic Acid Acyl--D-Glucuronide is a key conjugated metabolite of niacin (vitamin B3), formed via the glucuronidation pathway. This compound is essential for researchers and manufacturers focused on metabolic studies, drug development, and analytical standard preparation. It is primarily utilized in the pharmaceutical, biotechnology, and diagnostic industries for applications such as pharmacokinetic research, biomarker analysis, and the development of reference materials.

Application

• Pharmacokinetic and Metabolism Studies: Used as a reference standard to investigate the metabolic fate and clearance pathways of niacin and related pharmaceutical compounds.
• Biomarker Analysis: Serves as a critical analytical standard in clinical and preclinical studies for the accurate quantification of niacin metabolites in biological fluids.
• Drug Development and Impurity Profiling: Employed in pharmaceutical R&D to identify and characterize metabolites, supporting regulatory filings and safety assessments.
• Diagnostic Kit Manufacturing: Integrated into the production of calibration standards and controls for diagnostic assays measuring vitamin B3 status.
• Academic and Contract Research: A vital reagent for universities and CROs conducting fundamental research on nutrient metabolism and conjugation enzymology.
• Quality Control Reference Standard: Used by analytical laboratories and chemical suppliers to verify the purity and identity of niacin metabolite batches.

Basic Information

Product Name	Nicotinic Acid Acyl--D-Glucuronide
CAS No.	24719-73-1
Molecular Formula	C12H15NO9
Molecular Weight	317.25 g/mol
Synonyms	Nicotinuric Acid Glucuronide; Nicotinoyl Glucuronide; Acyl Glucuronide of Nicotinic Acid; Niacin Acyl Glucuronide; Nicotinic Acid β-D-Glucuronide; 1-O-(Nicotinoyl)-β-D-glucopyranuronic Acid; N-[(2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-[(1-oxidopyridin-1-ium-3-carbonyl)oxy]oxan-2-yl]formamide; Vitamin B3 Acyl Glucuronide
EINECS	Contact for details

Quality Control

Our Nicotinic Acid Acyl--D-Glucuronide is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.