Description

1,4-Pregnadien-9Alpha-Fluoro-16Alpha-Methyl-11Beta, 17Alpha, 21-Triol 3,20-Dione 21-T-Butylacetate is a high-purity synthetic steroid intermediate of significant importance in pharmaceutical research and development. This compound serves as a critical precursor in the synthesis of potent glucocorticoid and anti-inflammatory agents. It is primarily needed by pharmaceutical manufacturers, R&D laboratories, and fine chemical producers engaged in advanced steroid chemistry and novel drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of advanced corticosteroid drugs, including anti-inflammatory and immunosuppressive agents.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new therapeutic compounds targeting glucocorticoid receptors.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Process Chemistry: Employed in scale-up and optimization of synthetic routes for steroid-based active pharmaceutical ingredients (APIs).
• Biochemical Research: Utilized in studies investigating steroid hormone metabolism, receptor binding, and related biochemical pathways.

Basic Information

Product Name	1,4-Pregnadien-9Alpha-Fluoro-16Alpha-Methyl-11Beta, 17Alpha, 21-Triol 3,20-Dione 21-T-Butylacetate
CAS No.	24668-75-5
Molecular Formula	C₂₈H₃₉FO₆
Molecular Weight	490.61 g/mol
Synonyms	9α-Fluoro-16α-methylprednisolone 21-t-butylacetate; 9α-Fluoro-16α-methyl-1,4-pregnadiene-11β,17α,21-triol-3,20-dione 21-t-butylacetate; 16α-Methyl-9α-fluoroprednisolone 21-t-butylacetate; Fluocortolone 21-t-butylacetate intermediate; 1,4-Pregnadiene-9α-fluoro-16α-methyl-11β,17α,21-triol-3,20-dione 21-tert-butylacetate; 9α-Fluoro-16α-methylprednisolone tert-butylacetate; 24668-75-5; Fluocortolone butylacetate precursor
EINECS	Contact for details

Quality Control

Our 1,4-Pregnadien-9Alpha-Fluoro-16Alpha-Methyl-11Beta, 17Alpha, 21-Triol 3,20-Dione 21-T-Butylacetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles suitable for pharmaceutical intermediate applications, ensuring reliable supply and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep the container sealed when not in use to prevent contamination and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.