Description

Guanosine-8-3H Hydrochloride is a tritium-labeled derivative of guanosine, a fundamental nucleoside building block. This labeled compound is essential for researchers requiring high-sensitivity detection and precise metabolic tracing in biochemical studies. It is primarily utilized by scientists in the pharmaceutical, biotechnology, and academic research sectors for applications such as nucleotide metabolism research, enzyme assay development, and receptor binding studies.

Application

• Biochemical Research & Nucleotide Metabolism Studies: Used as a radiolabeled tracer to investigate the synthesis, turnover, and metabolic pathways of guanine nucleotides.
• Enzyme Kinetics & Assay Development: Serves as a critical substrate or ligand in assays for enzymes like kinases, phosphorylases, and nucleotidyltransferases.
• Receptor-Ligand Binding Studies: Employed in radio-ligand binding assays to study purinergic receptors (e.g., adenosine receptors) and other nucleotide-binding proteins.
• Molecular Biology & Virology: Can be used in research involving viral replication mechanisms that depend on host nucleotide pools.
• Drug Discovery & Development: Facilitates the study of drug candidates that target nucleotide synthesis pathways, such as anticancer or antiviral agents.
• Diagnostic Kit Development: Acts as a key component in the development of sensitive diagnostic assays and research kits.

Basic Information

Product Name	Guanosine-8-3H Hydrochloride
CAS No.	24613-04-5
Molecular Formula	C₁₀H₁₄ClN₅O₅
Molecular Weight	319.70 g/mol
Synonyms	8-3H-Guanosine Hydrochloride; [8-3H]Guanosine HCl; Tritiated Guanosine Hydrochloride; Guanosine-8-tritium Hydrochloride; 2-Amino-1,9-dihydro-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6H-purin-6-one-8-3H Hydrochloride; 9-β-D-Ribofuranosylguanine-8-3H Hydrochloride
EINECS	Contact for details

Quality Control

Our Guanosine-8-3H Hydrochloride is produced and handled under stringent quality protocols to ensure batch-to-batch consistency and radiochemical purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing critical parameters such as radiochemical purity, specific activity, and chemical purity. We adhere to relevant quality standards for research chemicals to support reproducible and reliable scientific results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled in a controlled environment to minimize exposure to atmospheric moisture. For long-term storage of radioactive materials, follow all local and institutional radiation safety guidelines.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Assay (HPLC)	≥ 95% (Chemical Purity)
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	10-40 Ci/mmol (Contact for exact value)
Solvent (for specific batches)	Ethanol:Water solution

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.