Description

4-(2-Bromoacetamido)-2,2,6,6-Tetramethyl-1-Piperidinyloxy is a specialized nitroxide radical compound, widely recognized as a spin-labeling reagent and a versatile intermediate in organic synthesis. Its core value lies in its stable free radical character, enabling its use as a paramagnetic probe in Electron Paramagnetic Resonance (EPR) spectroscopy for studying molecular dynamics and structure. This compound is essential for researchers and manufacturers in the fields of biophysical chemistry, polymer science, and materials research, where precise molecular tagging and analysis are required.

Application

• Spin-Labeling for EPR/ESR Spectroscopy: Acts as a paramagnetic tag to study protein dynamics, membrane fluidity, and polymer chain mobility.
• Bioconjugation & Protein Labeling: The bromoacetamido group enables selective covalent attachment to thiol groups (cysteine residues) in proteins and peptides.
• Polymer & Materials Science: Used as a stable radical initiator or modifier in controlled radical polymerization and to create functionalized polymer surfaces.
• Molecular Probe Development: Serves as a key building block for synthesizing advanced probes for oxidative stress detection and imaging.
• Pharmaceutical Research: Utilized in the development of nitroxide-based antioxidants and contrast agents.
• Crosslinking Agent: Can function as a bifunctional reagent for introducing stable radical sites or crosslinks into biomolecules.

Basic Information

Product Name	4-(2-Bromoacetamido)-2,2,6,6-Tetramethyl-1-Piperidinyloxy
CAS No.	24567-97-3
Molecular Formula	C11H20BrN2O2
Molecular Weight	289.19 g/mol
Synonyms	4-(2-Bromoacetamido)-TEMPO; 4-(Bromoacetamido)-2,2,6,6-tetramethylpiperidine-1-oxyl; 4-Bromoacetamido-TEMPO; 4-(Bromoacetamido)-TEMPO; 2,2,6,6-Tetramethyl-4-(2-bromoacetamido)-1-piperidinyloxy; 4-(2-Bromoacetamido)-2,2,6,6-tetramethylpiperidin-1-oxyl; 4-Bromoacetamido-2,2,6,6-tetramethylpiperidine-1-oxyl; TEMPO-Bromoacetamide
EINECS	Contact for details

Quality Control

Our production of 4-(2-Bromoacetamido)-2,2,6,6-Tetramethyl-1-Piperidinyloxy adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analysis, including assay by HPLC, verification of radical content by EPR, and impurity profiling. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation.

Specification

Item	Specification
Appearance	Orange to red crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Radical Content (EPR)	≥ 95%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.