Description

Cortisol 21-2-D-Glucuronide Methyl Ester 2,3,5-Triacetate is a key synthetic derivative of cortisol, specifically designed for advanced research and analytical applications. This compound serves as a critical intermediate and reference standard in the development and validation of analytical methods for steroid hormone analysis. It is primarily utilized by pharmaceutical R&D laboratories, clinical diagnostic manufacturers, and academic research institutions focused on endocrinology and metabolomics. Its defined structure is essential for ensuring accuracy and reliability in complex biochemical assays.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the calibration of analytical instruments in drug development and quality control.
• Clinical Diagnostics: Serves as a critical component in the development and manufacturing of immunoassay kits for cortisol and related metabolite detection.
• Metabolomics Research: Employed in mass spectrometry (MS) and high-performance liquid chromatography (HPLC) studies to investigate cortisol metabolism pathways.
• Biochemical Synthesis: Acts as a protected intermediate in the synthetic route for producing novel cortisol analogs and labeled compounds for tracer studies.
• Academic Research: Utilized in university and institutional labs for fundamental studies on steroid biochemistry, receptor interactions, and enzyme kinetics.
• Method Development & Validation: Essential for establishing and validating new analytical protocols in compliance with regulatory guidelines (e.g., FDA, ICH).

Basic Information

Product Name	Cortisol 21-2-D-Glucuronide Methyl Ester 2,3,5-Triacetate
CAS No.	24562-21-8
Molecular Formula	C36H48O15
Molecular Weight	720.76 g/mol
Synonyms	Cortisol 21-Glucuronide Methyl Ester Triacetate; 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione 21-(2,3,5-tri-O-acetyl-β-D-glucopyranuronate) Methyl Ester; Hydrocortisone 21-Glucuronide Methyl Ester 2',3',5'-Triacetate; Cortisol D-21-Glucuronide Methyl Ester Triacetate; (11β)-11,17,21-Trihydroxypregn-4-ene-3,20-dione 21-(2,3,5-tri-O-acetyl-β-D-glucopyranosiduronate) Methyl Ester
EINECS	Contact for details

Quality Control

Our Cortisol 21-2-D-Glucuronide Methyl Ester 2,3,5-Triacetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and diagnostic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment to maintain stability. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.