Description

Doxycycline Hyclate is a semi-synthetic, broad-spectrum tetracycline antibiotic. It is highly valued for its potent antibacterial activity against a wide range of Gram-positive and Gram-negative organisms, mycoplasmas, and certain protozoa. This compound is a critical active pharmaceutical ingredient (API) primarily required by pharmaceutical manufacturers for the formulation of oral and injectable antibiotic medications.

Application

• Pharmaceutical API: Primary use in the manufacture of oral capsules, tablets, and injectable solutions for treating bacterial infections.
• Veterinary Medicine: Formulated into medicated feeds, powders, and injectables for livestock, poultry, and companion animals.
• Treatment of Specific Infections: Effective for respiratory tract infections, urinary tract infections, sexually transmitted diseases, acne, and malaria prophylaxis.
• Research & Development: Used as a standard reference material and in biochemical research to study bacterial protein synthesis inhibition.
• Aquaculture: Employed in the treatment of bacterial diseases in farmed fish and shellfish.

Basic Information

Item	Details
Product Name	Doxycycline Hyclate
CAS No.	24390-14-5
Molecular Formula	C22H24N2O8 · HCl · ½C2H6O · ½H2O
Molecular Weight	512.94 g/mol
Synonyms	Doxycycline Hydrochloride Hemethanolate Hemihydrate; Doxycycline HCl; GS-3065; Vibramycin; Monodox; Doryx; Periostat; (4S,4aR,5S,5aR,6R,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide hydrochloride, compound with ethanol (1:0.5), hydrate (1:0.5)
EINECS	Contact for details

Quality Control

Our Doxycycline Hyclate is manufactured under cGMP (current Good Manufacturing Practice) conditions to ensure the highest standards of purity and consistency. Each batch undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling, to meet or exceed USP/EP/BP monograph specifications. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and potency.

Specification

Item	Specification
Appearance	Yellow to yellow-orange crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC, anhydrous basis)	95.0% - 102.0%
pH (1% suspension)	2.0 - 3.5
Water (Karl Fischer)	1.5% - 3.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.2%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%
Ethanol Content (GC)	4.0% - 6.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.