Description

Naloxol-3-Glucuronide is a major, pharmacologically inactive metabolite of naloxone, formed via glucuronidation. This reference standard is critical for analytical research and method development in forensic and clinical toxicology. It is primarily used by pharmaceutical R&D laboratories and analytical service providers for the accurate quantification of naloxone and its metabolites in biological matrices, ensuring reliable pharmacokinetic and bioequivalence studies.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the calibration and validation of analytical methods in drug metabolism and pharmacokinetics (DMPK) studies.
• Forensic Toxicology: Essential for the identification and quantification of naloxone metabolites in urine, blood, or plasma samples, supporting medico-legal investigations.
• Clinical Research: Employed in bioanalytical assays to study the metabolic profile and clearance of naloxone in human subjects during clinical trials.
• Quality Control (QC) Testing: Serves as an internal standard in HPLC-MS/MS or GC-MS systems to ensure the accuracy and precision of naloxone assay methods in pharmaceutical manufacturing.
• Metabolite Synthesis & Research: Acts as a key intermediate or standard for further chemical synthesis and research into opioid antagonist metabolism pathways.

Basic Information

Product Name	Naloxol-3-Glucuronide
CAS No.	24326-39-4
Molecular Formula	C25H31NO10
Molecular Weight	505.52 g/mol
Synonyms	Naloxone 3-Glucuronide; Naloxol Glucuronide; 17-Allyl-4,5α-epoxy-3,14-dihydroxymorphinan-6-one 3-β-D-Glucuronide; Noroxymorphone 3-Glucuronide (related); Naloxone Metabolite; 3-Glucuronide of Naloxol; Naloxone-3-β-D-Glucuronide
EINECS	Contact for details

Quality Control

Our Naloxol-3-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS), to ensure it meets high-purity standards suitable for analytical and research applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.