Description

Cephalotaxine CAS NO 24316-19-6 is a key pentacyclic alkaloid and the core structural framework for the clinically significant Cephalotaxus ester alkaloids. This compound matters as a critical intermediate and reference standard in pharmaceutical research and development, particularly for anticancer agent synthesis. It is primarily needed by research institutions, pharmaceutical companies, and fine chemical manufacturers engaged in oncology drug discovery, natural product chemistry, and the production of high-purity biochemical reagents.

Application

• Pharmaceutical Intermediate: Serves as the essential precursor for the semi-synthesis of homoharringtonine and other harringtonine-type anticancer alkaloids.
• Biochemical Research: Used as a reference standard in analytical methods (HPLC, LC-MS) for quality control and quantification of Cephalotaxus extracts and related compounds.
• Anticancer Drug Discovery: Acts as a core scaffold for structure-activity relationship (SAR) studies and the development of novel chemotherapeutic agents targeting leukemia and other cancers.
• Natural Product Isolation & Synthesis: Employed in the isolation, purification, and total synthesis studies of complex plant-derived alkaloids.
• Academic & Clinical Research: Utilized in pharmacological studies to investigate mechanisms of action, cytotoxicity, and apoptosis induction in cancer cell lines.

Basic Information

Product Name	Cephalotaxine
CAS No.	24316-19-6
Molecular Formula	C18H21NO4
Molecular Weight	315.36 g/mol
Synonyms	Cephalotaxin; Cephalotaxine Base; (1S,3aR,14bS)-2,3,3a,4,5,14b-Hexahydro-1-hydroxy-1H-benzo[6,7]cyclohepta[1,2,3-ij]isoquinoline-6,8,10(9H)-trione; 1-Hydroxy-2,3-methylenedioxy-6,7-seco-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine-6,7-dione
EINECS	Contact for details

Quality Control

Our Cephalotaxine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets high-purity standards suitable for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, residual solvents, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.