Description

(S)-2,2-Dimethyl-1,3-Dioxolane-4-Methanol p-Toluenesulfonate is a high-purity chiral building block and synthetic intermediate, specifically the p-toluenesulfonate (tosylate) ester derivative of (S)-isopropylidene glycerol. This compound is valued for its role as a protected chiral synthon, enabling the stereoselective introduction of glycerol-derived moieties into more complex molecules. It is primarily sought after by research and development chemists and process scale-up teams in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of active pharmaceutical ingredients (APIs), ligands, and other fine chemicals where chirality is critical.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of β-blockers, antiviral agents, and other active pharmaceutical ingredients (APIs) requiring specific stereochemistry.
• Asymmetric Synthesis: Serves as a versatile chiral building block for constructing complex molecules in medicinal chemistry and total synthesis projects.
• Ligand and Catalyst Preparation: Used in the development of chiral ligands for asymmetric catalysis and organometallic complexes.
• Agrochemical Synthesis: Intermediate in the production of chiral pesticides and herbicides where biological activity is enantiomer-specific.
• Polymer Chemistry: Potential monomer or modifier for creating polymers with specific chiral or functional properties.
• Academic & Industrial R&D: Essential reagent for methodological development and exploratory synthesis in organic chemistry laboratories.

Basic Information

Product Name	(S)-2,2-Dimethyl-1,3-Dioxolane-4-Methanol p-Toluenesulfonate
CAS No.	23735-43-5
Molecular Formula	C13H18O5S
Molecular Weight	286.34 g/mol
Synonyms	(S)-(-)-1,2-Isopropylidene Glycerol 3-p-Toluenesulfonate; (S)-(-)-1,2-O-Isopropylidene Glycerol 3-Tosylate; (S)-1,2-O-Isopropylidene-3-O-tosylglycerol; (S)-3-O-Tosyl-1,2-O-isopropylideneglycerol; (S)-Isopropylidene Glycerol Tosylate; (S)-Solketal Tosylate; (S)-1,2-O-Cyclohexylidene Glycerol 3-Tosylate (related); (S)-Glycerol Acetonide Tosylate
EINECS	Contact for details

Quality Control

Our (S)-2,2-Dimethyl-1,3-Dioxolane-4-Methanol p-Toluenesulfonate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity. We provide comprehensive analytical data, including Chiral HPLC to confirm enantiomeric excess and standard purity assays. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every batch upon request, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque packaging or amber glass.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.