Description

Homobatrachotoxin is a potent steroidal alkaloid neurotoxin, structurally related to batrachotoxin. This compound is of significant interest in biochemical and pharmacological research due to its specific and high-affinity interaction with voltage-gated sodium channels. It serves as a critical tool for neuroscientists and toxicologists studying ion channel function, neurophysiology, and the development of novel therapeutic agents. The product is supplied as Homobatrachotoxin CAS NO 23509-17-3 for global research and development applications.

Application

• Neuroscience Research: As a highly specific ligand for studying the structure and function of voltage-gated sodium channels in neuronal cells.
• Pharmacology & Toxicology: Used in assays to investigate mechanisms of neurotoxicity, cardiotoxicity, and to evaluate potential antidotes or channel blockers.
• Ion Channel Drug Discovery: A key reference compound in high-throughput screening (HTS) campaigns aimed at discovering new analgesics, anesthetics, or antiarrhythmic drugs.
• Biochemical Studies: Employed in binding experiments and patch-clamp electrophysiology to characterize channel kinetics and gating properties.
• Comparative Toxinology: Used in research to understand the evolution of chemical defenses in poison dart frogs and related species.
• Analytical Standard: Serves as a certified reference material (CRM) for the qualitative and quantitative analysis of steroidal alkaloids in complex matrices.

Basic Information

Item	Detail
Product Name	Homobatrachotoxin
CAS No.	23509-17-3
Molecular Formula	C32H44N2O6
Molecular Weight	552.71 g/mol
Synonyms	Homobatrachotoxin; 20α-Hydroxybatrachotoxinin A 3β-(2,4-dimethylpyrrole-5-carboxylate); Batrachotoxin homologue; 3β-(2,4-Dimethyl-1H-pyrrole-5-carboxyloxy)-14β,18β-epoxy-4β,9α-epoxy-5β-card-20(22)-enolide, 20α-hydroxy-; (3β,4β,9α,14β,16β,20α)-20-Hydroxy-4,9-epoxy-3-(2,4-dimethyl-1H-pyrrole-5-carboxyloxy)card-20(22)-enolide
EINECS	Contact for details

Quality Control

Every batch of Homobatrachotoxin is produced and handled under strict quality management protocols to ensure identity, purity, and stability for critical research applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing comprehensive analytical results from techniques including HPLC, NMR, and MS.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.