Description

6Alpha-Fluoro-11Beta,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione 17-Valerate is a synthetic corticosteroid derivative, specifically a fluorinated pregnadiene valerate ester. This compound is a critical pharmaceutical intermediate valued for its potent anti-inflammatory and immunosuppressive activity. It is primarily utilized by research institutions and pharmaceutical manufacturers in the development and production of advanced topical and systemic corticosteroid medications.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potent topical corticosteroids for treating dermatological conditions like eczema, psoriasis, and dermatitis.
• Active Pharmaceutical Ingredient (API) Development: Serves as a precursor in the research and manufacturing of steroid-based APIs for anti-inflammatory and immunosuppressive therapies.
• Biochemical Research: Used in laboratory studies to investigate glucocorticoid receptor activity, steroid metabolism, and mechanisms of inflammation.
• Veterinary Medicine: Employed in the formulation of anti-inflammatory treatments for skin and allergic conditions in animals.
• Reference Standard: Acts as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical laboratories.

Basic Information

Product Name	6Alpha-Fluoro-11Beta,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione 17-Valerate
CAS No.	23257-44-5
Molecular Formula	C26H35FO7
Molecular Weight	478.55 g/mol
Synonyms	Fludrocortisone 17-Valerate; 6α-Fluoro-11β,17,21-trihydroxypregna-1,4-diene-3,20-dione 17-valerate; Fluocortolone 17-Valerate; Fluocortolone Caproate (common misnomer); 9α-Fluoro-16α-methylprednisolone 17-valerate (related compound name); NSC 121698; Fludrocortisone Valerate; Pregna-1,4-diene-3,20-dione, 6-fluoro-11,17,21-trihydroxy-, 17-valerate
EINECS	Contact for details

Quality Control

Our 6Alpha-Fluoro-11Beta,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione 17-Valerate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and stringent control of related substances and residual solvents. We provide a Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a desiccated environment away from direct light exposure to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.