Description

Hypoxanthine, [8-14C] is a carbon-14 labeled derivative of the purine base hypoxanthine, specifically radiolabeled at the 8-position. This compound is a critical tool for metabolic pathway tracing and nucleic acid research, enabling precise tracking of purine salvage and degradation in biological systems. It is essential for researchers and quality control laboratories in the pharmaceutical, biotechnology, and life science sectors who require high-specific-activity tracers for advanced studies in enzymology, oncology, and drug metabolism.

Application

• Metabolic Pathway Tracing: Used as a radiolabeled tracer to study purine metabolism, salvage pathways, and nucleotide interconversion in cell cultures and animal models.
• Enzyme Kinetics & Inhibition Studies: Serves as a substrate for enzymes like xanthine oxidase and hypoxanthine-guanine phosphoribosyltransferase (HGPRT) to investigate enzyme mechanisms and screen for potential inhibitors.
• Nucleic Acid Research: Employed in the study of DNA/RNA synthesis and repair mechanisms where purine base incorporation and turnover are monitored.
• Drug Development & ADME Studies: Facilitates Absorption, Distribution, Metabolism, and Excretion (ADME) studies for pharmaceutical compounds that interact with purine metabolic pathways.
• Biochemical Assay Development: Acts as a key component in developing sensitive radiometric assays for clinical diagnostics and biochemical research.
• Oncology Research: Used to investigate altered purine metabolism in cancer cells, a hallmark of many malignancies.

Basic Information

Product Name	Hypoxanthine, [8-14C]
CAS No.	23199-34-0
Molecular Formula	C₅H₄N₄O * ([14C] at position 8)
Molecular Weight	~136.11 g/mol (exact mass depends on specific activity)
Synonyms	1H-Purin-6(9H)-one, [8-14C]; 6-Hydroxypurine, [8-14C]; Purin-6-ol, [8-14C]; [8-14C]-Hypoxanthine; 14C-Hypoxanthine; Hypoxanthine-8-14C; Hypoxanthine (8-14C); Radiolabeled Hypoxanthine
EINECS	Contact for details

Quality Control

Every batch of Hypoxanthine, [8-14C] is manufactured and analyzed under strict quality systems to ensure identity, purity, and specific activity. Our products undergo rigorous quality testing, including radiochemical purity analysis by HPLC and TLC, specific activity determination, and chemical identity confirmation. Certificates of Analysis (COA) detailing all analytical results, including radionuclidic purity and solvent content, are provided with each shipment to ensure full traceability and compliance with research standards.

Storage

Preserve in a tightly closed container, protected from light. Store at or below -20°C. This product is hygroscopic (moisture-sensitive). For long-term storage, keep the container in a dry, inert atmosphere. Follow all applicable local and international regulations for the safe storage and handling of radioactive materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC, MS)	Conforms to reference standard
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Chemical Purity (HPLC)	≥ 98%
Solvent (Residual)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.