Description

Dehydroretronecine is a pyrrolizidine alkaloid intermediate of significant interest in pharmaceutical and biochemical research. This compound serves as a crucial building block for the synthesis and study of more complex pyrrolizidine alkaloids, which are a major focus in toxicology and drug discovery. It is primarily utilized by research institutions, pharmaceutical R&D departments, and chemical manufacturers engaged in the development of reference standards or novel therapeutic agents.

Application

• Pharmaceutical Research Intermediate: A key precursor in the synthesis and structural modification of pyrrolizidine alkaloids for biological activity studies.
• Toxicology Reference Standard: Used as an analytical standard to identify, quantify, and study the metabolism and toxicity of pyrrolizidine alkaloids in food, herbal products, and biological samples.
• Biochemical Probe: Employed in mechanistic studies to understand the bioactivation pathways and hepatotoxic effects associated with pyrrolizidine alkaloid poisoning.
• Chemical Synthesis Building Block: Serves as a versatile scaffold for medicinal chemists in the design and creation of new chemical entities for pharmacological screening.
• Quality Control & Method Development: Essential for developing and validating analytical methods (e.g., HPLC, LC-MS) in laboratories ensuring product safety and regulatory compliance.

Basic Information

Product Name	Dehydroretronecine
CAS No.	23107-12-2
Molecular Formula	C₈H₁₁NO₂
Molecular Weight	153.18 g/mol
Synonyms	1,2-Dehydroretronecine; (1R,7aR)-1-Hydroxy-2,3,5,7a-tetrahydro-1H-pyrrolizin-7-one; 7a-Hydroxy-1,2-dehydro-8α-pyrrolizidine; DHR; Dehydroretronecin
EINECS	Contact for details

Quality Control

Our Dehydroretronecine is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods and purity assessment by chromatography, to ensure it meets the high standards required for research applications. A Certificate of Analysis (COA) detailing specific results is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container sealed to protect the contents from moisture and contamination.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.