Description

Disuccinimidyl Sebacate is a homobifunctional N-hydroxysuccinimide (NHS) ester crosslinker, a critical reagent for creating stable amide bonds between primary amines. This compound matters for its role in bioconjugation, offering a defined 10-atom spacer arm that provides flexibility and distance between conjugated molecules. Researchers and manufacturers in the fields of biopharmaceutical development, proteomics, and diagnostic assay production rely on it for labeling antibodies, modifying proteins, and immobilizing biomolecules.

Application

• Protein-Protein Crosslinking: For conjugating antibodies, enzymes, or other proteins to create stable complexes for immunoassays and therapeutic applications.
• Peptide and Protein Labeling: Conjugation of fluorescent dyes, biotin, or other reporter molecules to primary amine-containing biomolecules.
• Surface Immobilization: Functionalizing beads, plates, or biosensor surfaces with proteins or peptides for capture assays and affinity purification.
• Antibody-Drug Conjugate (ADC) Research: Used in linker chemistry development for attaching cytotoxic payloads to monoclonal antibodies.
• Polymer Modification: Introducing amine-reactive sites onto polymers or dendrimers for advanced material science applications.
• Biomaterial Fabrication: Creating crosslinked hydrogels or matrices for tissue engineering and controlled drug release systems.

Basic Information

Product Name	Disuccinimidyl Sebacate
CAS No.	23024-29-5
Molecular Formula	C18H24N2O8
Molecular Weight	396.39 g/mol
Synonyms	DSS; Sebacoyl bis(N-succinimidyl) ester; Bis(N-succinimidyl) sebacate; N,N'-Disuccinimidyl sebacate; Sebacoyldisuccinimidyl ester; 1,10-Bis[(2,5-dioxo-1-pyrrolidinyl)oxy]-1,10-dioxodecane; DSC (in some contexts); Homobifunctional NHS ester crosslinker (C10)
EINECS	Contact for details

Quality Control

Our Disuccinimidyl Sebacate is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is characterized by HPLC, NMR, and mass spectrometry to confirm identity and purity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Solubility	Soluble in DMF, DMSO, acetonitrile
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.