Description

1-(3-Dimethylaminopropyl)-3-Ethylcarbodiimide Methiodide is a water-soluble carbodiimide derivative widely used as a zero-length crosslinking and coupling agent. This compound is essential for facilitating amide bond formation between carboxylic acids and amines under mild, aqueous conditions, making it a cornerstone reagent in bioconjugation. It is critically needed by researchers and manufacturers in pharmaceutical development, proteomics, and peptide synthesis for creating stable conjugates, modifying biomolecules, and developing novel therapeutic agents.

Application

• Peptide Synthesis: As a coupling agent for the formation of peptide bonds in solid-phase and solution-phase synthesis.
• Protein Crosslinking & Bioconjugation: For immobilizing enzymes, antibodies, or other proteins to solid supports (e.g., resins, chips) or for creating antibody-drug conjugates (ADCs).
• Nucleic Acid Modification: In the preparation of labeled probes or oligonucleotide conjugates for diagnostic and research applications.
• Carbohydrate Chemistry: For the synthesis of glycoconjugates by linking sugars to proteins or other carriers.
• Material Science: Surface functionalization of polymers, nanoparticles, and other materials to introduce bioactive groups.
• Pharmaceutical Intermediates: Used in the synthesis of active pharmaceutical ingredients (APIs) and prodrugs requiring amide linkages.

Basic Information

Product Name	1-(3-Dimethylaminopropyl)-3-Ethylcarbodiimide Methiodide
CAS No.	22572-40-3
Molecular Formula	C9H19IN3
Molecular Weight	296.17 g/mol
Synonyms	EDC Methiodide; 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide Methiodide; 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide Methyl Iodide; EDC.I; EDC Methiodide Salt; WSC Methiodide; Water-Soluble Carbodiimide Methiodide; (3-Dimethylaminopropyl)ethylcarbodiimide Methiodide
EINECS	Contact for details

Quality Control

Our 1-(3-Dimethylaminopropyl)-3-Ethylcarbodiimide Methiodide is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and industrial applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and efficacy.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.