Description

α-Decitabine CAS NO 22432-95-7 is a potent nucleoside analog and DNA methyltransferase inhibitor, playing a critical role in epigenetic regulation. This compound is essential for research and development in targeted cancer therapies, particularly for myelodysplastic syndromes and acute myeloid leukemia. It is a key raw material for pharmaceutical manufacturers, research institutions, and biotechnology companies focused on oncology and epigenetics.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the active pharmaceutical ingredient in formulations for the treatment of hematological malignancies.
• Oncology Research: Critical tool in preclinical and clinical research for studying DNA methylation, gene silencing, and cancer cell differentiation.
• Epigenetics Studies: Used in laboratory settings to investigate epigenetic modifications and their role in disease progression and cellular reprogramming.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical testing laboratories.
• Drug Development: A vital intermediate in the synthesis and development of novel epigenetic therapies and combination treatments.

Basic Information

Item	Details
Product Name	α-Decitabine
CAS No.	22432-95-7
Molecular Formula	C8H12N4O4
Molecular Weight	228.21 g/mol
Synonyms	5-Aza-2'-deoxycytidine; 5-Aza-dC; Dacogen (brand name); Dezocitidine; NSC 127716; 4-Amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one; 2'-Deoxy-5-azacytidine
EINECS	Contact for details

Quality Control

Our α-Decitabine is manufactured under strict quality systems to meet the rigorous standards required for pharmaceutical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We ensure compliance with relevant pharmacopeial guidelines and support customer-specific validation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.