Description

(R)-(-)-Coniine CAS NO 22160-08-3 is a chiral alkaloid and the principal toxic constituent of poison hemlock (Conium maculatum). This high-purity enantiomer is of significant value in research and development, serving as a critical reference standard and a versatile chiral building block. It is primarily sought by the pharmaceutical, agrochemical, and academic research sectors for applications in asymmetric synthesis, toxicology studies, and the development of bioactive compounds.

Application

• Pharmaceutical Research & Development: As a key chiral intermediate or reference standard in the synthesis of novel bioactive molecules and active pharmaceutical ingredients (APIs).
• Toxicology & Forensic Analysis: Used as a certified reference material (CRM) for the accurate identification and quantification of coniine in forensic, clinical, and environmental samples.
• Agrochemical Research: Employed as a lead compound or synthetic precursor in the development of new, selective pesticides and herbicides.
• Academic & Biochemical Studies: Serves as a tool compound for investigating nicotinic acetylcholine receptor (nAChR) activity and studying plant-derived neurotoxins.
• Asymmetric Synthesis: Utilized as a chiral pool reagent or catalyst ligand in stereoselective chemical transformations.

Basic Information

Item	Details
Product Name	(R)-(-)-Coniine
CAS No.	22160-08-3
Molecular Formula	C8H17N
Molecular Weight	127.23 g/mol
Synonyms	(R)-2-Propylpiperidine; (R)-Coniine; (-)-Coniine; (R)-(-)-Coniine; (2R)-2-Propylpiperidine; D-Coniine; (R)-Coniceine; Coniine, (R)-(-)-; Coniin
EINECS	244-804-5

Quality Control

Every batch of our (R)-(-)-Coniine is produced and tested under strict quality management systems. We guarantee high chemical and chiral purity, with comprehensive testing including HPLC for assay, chiral analysis for enantiomeric excess (e.e.), and spectroscopic identification (IR, NMR). A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic and highly volatile nature, the container must be kept tightly sealed under an inert atmosphere after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.