Description

3-o-(1-Hexadecyl)Cholesterol is a synthetic cholesterol derivative where a hexadecyl (C16) chain is ether-linked to the 3-position of the sterol backbone. This structural modification significantly alters its physicochemical properties, making it a valuable lipophilic anchor and membrane-modifying agent for advanced research and formulation development. It is primarily utilized by researchers and product developers in the pharmaceutical, biotechnology, and advanced materials sectors for creating stable liposomal systems, studying membrane dynamics, and developing novel drug delivery platforms.

Application

• Liposome and Lipid Nanoparticle (LNP) Formulation: Acts as a structural lipid to enhance membrane stability and modulate fluidity in drug delivery carriers.
• Biomimetic Membrane Research: Used in model membrane systems (e.g., vesicles, supported bilayers) to study the effect of alkylated sterols on membrane organization and protein interactions.
• Drug Delivery Enhancer: Incorporated into formulations to improve the encapsulation efficiency and sustained release of hydrophobic active pharmaceutical ingredients (APIs).
• Cosmetic Actives Carrier: Serves as a penetration enhancer and stabilizer in high-performance skincare formulations for active ingredients.
• Chemical Biology Probe: Utilized as a tool compound to investigate cholesterol trafficking, membrane domain (lipid raft) formation, and related cellular processes.
• Material Science: A precursor or additive in the synthesis of functionalized polymers and smart materials with specific surface properties.

Basic Information

Product Name	3-o-(1-Hexadecyl)Cholesterol
CAS No.	22032-48-0
Molecular Formula	C₄₃H₇₈O
Molecular Weight	611.09 g/mol
Synonyms	Cholesteryl Hexadecyl Ether; 3-(Hexadecyloxy)cholest-5-ene; 3β-(Hexadecyloxy)-5-cholestene; 3-O-Hexadecylcholesterol; 1-Hexadecyl Cholesterol Ether; Cholesterol 3-Hexadecyl Ether; 5-Cholesten-3β-ol, 3-(hexadecyloxy)-; Lipophilic Cholesterol Derivative
EINECS	Contact for details

Quality Control

Our 3-o-(1-Hexadecyl)Cholesterol is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with detailed results from techniques such as HPLC, NMR, and MS. Our quality commitment aligns with the standards required for research and cGMP-grade applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.