Description

1-(2'-Deoxyribosyl)-2-Pyrimidinone is a modified nucleoside derivative, a key building block in nucleic acid chemistry and biochemistry. This compound is essential for research and development in the fields of oligonucleotide synthesis and medicinal chemistry, where precise molecular structures are required. It is primarily utilized by pharmaceutical R&D teams, diagnostic manufacturers, and academic research institutions focused on nucleotide analogs, antisense technology, and prodrug development.

Application

• Oligonucleotide Synthesis: Serves as a crucial intermediate or modified base in the solid-phase synthesis of DNA and RNA analogs for research and therapeutic applications.
• Antisense & siRNA Development: Used in the creation of nucleotide analogs for gene silencing technologies, targeting specific mRNA sequences.
• Medicinal Chemistry & Prodrug Design: Acts as a building block for developing nucleoside-based prodrugs and antiviral or anticancer agents.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies to understand DNA repair mechanisms and polymerase activity.
• Diagnostic Probe Development: Utilized in the design and synthesis of labeled probes for genetic testing and molecular diagnostics.
• Reference Standard: Functions as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	1-(2'-Deoxyribosyl)-2-Pyrimidinone
CAS No.	22003-30-1
Molecular Formula	C9H12N2O5
Molecular Weight	228.20 g/mol
Synonyms	2-Pyrimidinone, 1-(2-deoxy-β-D-erythro-pentofuranosyl)-; 1-(2-Deoxy-β-D-ribofuranosyl)-2-pyrimidinone; 2'-Deoxy-2-pyrimidinone riboside; 1-(2-Deoxyribosyl)-2(1H)-pyrimidinone; dP; 2-Pyrimidinone deoxyriboside; 2-Oxopyrimidine deoxyribonucleoside
EINECS	Contact for details

Quality Control

Our 1-(2'-Deoxyribosyl)-2-Pyrimidinone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.