Description

o-Demethylpuromycin is a key intermediate and derivative of the potent protein synthesis inhibitor puromycin. This compound is of significant value in biochemical and pharmaceutical research, particularly in the study of ribosome function and antibiotic mechanisms. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in the development of novel antimicrobial agents and molecular biology tools.

Application

• Biochemical Research: Critical intermediate for studying the structure-activity relationship (SAR) of puromycin and its analogs.
• Antibiotic Mechanism Studies: Used as a tool compound to investigate protein synthesis inhibition and ribosome function.
• Pharmaceutical Development: Serves as a building block in the synthesis of novel puromycin derivatives for potential therapeutic applications.
• Molecular Biology: Employed in specialized assays to understand translational fidelity and termination.
• Academic Research: Utilized in university and institutional labs for fundamental research in microbiology and biochemistry.

Basic Information

Product Name	o-Demethylpuromycin
CAS No.	21708-87-2
Molecular Formula	C₂₁H₂₈N₆O₄
Molecular Weight	428.49 g/mol
Synonyms	O-Demethylpuromycin; 3'-De-O-methylpuromycin; 3'-Demethylpuromycin; Puromycin, 3'-demethyl-; 6-Dimethylamino-9-[3-deoxy-3-(p-methoxy-L-phenylalanylamino)-β-D-ribofuranosyl]purine (related); Antibiotic CL 13900; Puromycin derivative; 3'-O-Demethylpuromycin
EINECS	Contact for details

Quality Control

Our o-Demethylpuromycin is produced under controlled conditions to ensure high purity and batch-to-batch consistency. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to meet the stringent requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.