Description

Thyroxine Glucuronide is a key conjugated metabolite of the thyroid hormone thyroxine (T4). This compound is of significant interest in biochemical research and pharmaceutical development, particularly for studying hormone metabolism and clearance pathways. It is primarily utilized by researchers and manufacturers in the fields of endocrinology, analytical chemistry, and drug metabolism and pharmacokinetics (DMPK).

Application

• Biochemical Research Standard: Serves as a critical reference standard in the study of thyroid hormone metabolism and glucuronidation pathways.
• Pharmaceutical Development: Used in DMPK studies to investigate the metabolic fate and excretion profiles of thyroid hormone analogs.
• Analytical Chemistry: Employed as a high-purity calibrant or internal standard in advanced analytical techniques like LC-MS/MS and HPLC for quantitative bioanalysis.
• Endocrinology Studies: Essential for in vitro and in vivo research focused on hormone conjugation, transport, and deactivation mechanisms.
• Diagnostic Assay Development: Can be used in the development and validation of immunoassays or other diagnostic tests for thyroid function and related disorders.

Basic Information

Product Name	Thyroxine Glucuronide
CAS No.	21462-56-6
Molecular Formula	C30H37I4NO11
Molecular Weight	1083.24 g/mol
Synonyms	L-Thyroxine O-glucuronide; T4 Glucuronide; Thyroxine β-D-Glucuronide; O-(β-D-Glucopyranuronosyl)-L-thyroxine; 3,3',5,5'-Tetraiodothyronine glucuronide; Levothyroxine glucuronide; (2S)-2-Amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid β-D-glucopyranosiduronic acid
EINECS	Contact for details

Quality Control

Our Thyroxine Glucuronide is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical characterization, including identity confirmation by spectroscopic methods and purity assessment by HPLC. A Certificate of Analysis (COA) detailing specific test results is provided with every shipment to guarantee product integrity and support your research documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content	≤ 5.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.