Description

4-Chlorophenylmercapturic Acid is a key mercapturic acid metabolite, serving as a critical biomarker for monitoring human exposure to specific industrial chemicals and environmental pollutants. Its precise detection is essential for toxicological studies, occupational health assessments, and regulatory compliance in safety monitoring. This high-purity reference standard is primarily required by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in biomonitoring, metabolism research, and method development.

Application

• Biomarker Analysis: Used as a certified reference standard in LC-MS/MS and HPLC methods for quantifying human exposure to chlorobenzene and related aromatic compounds.
• Toxicology & Occupational Health: Essential for biological monitoring programs to assess workplace exposure and ensure compliance with health and safety regulations (e.g., OSHA, EU directives).
• Metabolism and Pharmacokinetic Studies: Employed in research to elucidate metabolic pathways, specifically the glutathione conjugation pathway, for xenobiotics.
• Environmental Exposure Assessment: Aids in population-level studies measuring environmental pollutant uptake, supporting public health initiatives.
• Method Development & Validation: Serves as a critical calibrant and quality control material for developing and validating robust bioanalytical assays in clinical and forensic toxicology.
• Pharmaceutical Impurity Profiling: Can be utilized in stability testing and impurity identification for drug substances and products where related metabolites must be monitored.

Basic Information

Product Name	4-Chlorophenylmercapturic Acid
CAS No.	21462-48-6
Molecular Formula	C11H12ClNO4S
Molecular Weight	289.73 g/mol
Synonyms	N-Acetyl-S-(4-chlorophenyl)-L-cysteine; 4-Chloro-MA; S-(4-Chlorophenyl)-N-acetylcysteine; N-Acetyl-3-(4-chlorophenylthio)alanine; 4-Chlorophenyl-MA; Mercapturic acid of 4-chlorobenzene; (2R)-2-Acetamido-3-(4-chlorophenyl)sulfanylpropanoic acid
EINECS	Contact for details

Quality Control

Our 4-Chlorophenylmercapturic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for reference materials and research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.