Description

Isowillardiine is a naturally occurring, non-proteinogenic amino acid analog of willardiine, distinguished by its unique isoxazolidinone structure. This compound is of significant interest in biochemical and pharmacological research due to its role as a selective agonist for specific glutamate receptor subtypes. It serves as a critical high-purity reference standard and building block for scientists in neurochemistry, medicinal chemistry, and plant physiology.

Application

• Neuroscience Research: Used as a selective agonist for studying kainate and AMPA subtypes of ionotropic glutamate receptors.
• Medicinal Chemistry: Serves as a key intermediate or pharmacophore in the design and synthesis of novel neuroactive compounds.
• Biochemical Assays: Employed as a reference standard in HPLC, LC-MS, or NMR for method development and validation.
• Plant Biochemistry Studies: Investigated for its natural occurrence and potential physiological roles in certain plant species.
• Academic & Institutional Research: Essential for fundamental research into excitatory amino acid signaling pathways.

Basic Information

Product Name	Isowillardiine
CAS No.	21381-33-9
Molecular Formula	C7H9N3O4
Molecular Weight	199.16 g/mol
Synonyms	(S)-2-Amino-3-(1,2,4-oxadiazol-5-yl)propanoic acid; (S)-2-Amino-3-(1,2,4-oxadiazol-5-yl)propionic acid; L-Isowillardiine; 5-(1-Carboxy-2-aminoethyl)-1,2,4-oxadiazole; Willardiine isomer; α-Amino-β-(1,2,4-oxadiazol-5-yl)propionic acid
EINECS	Contact for details

Quality Control

Our Isowillardiine is produced under a strict quality management system to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant guidelines for research chemicals, ensuring reliable and reproducible performance in sensitive assays.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.