Description

8-Hydroxyguanosine Triphosphate is a modified nucleotide triphosphate analog of significant interest in biochemical and pharmaceutical research. This compound matters as a critical tool for studying oxidative stress, DNA damage, and repair mechanisms at the molecular level. It is primarily needed by research institutions, diagnostic developers, and pharmaceutical companies engaged in oncology, neurology, and aging-related research, where understanding oxidative nucleic acid damage is paramount.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies related to DNA/RNA synthesis and repair, particularly investigating the incorporation and effects of oxidized nucleotides.
• Diagnostic Assay Development: Serves as a key component or standard in developing assays (e.g., ELISA, HPLC-MS) to detect and quantify 8-hydroxyguanosine, a major biomarker of oxidative stress, in biological samples.
• Pharmaceutical Screening: Employed in high-throughput screening platforms to identify novel compounds that modulate enzymes involved in the metabolism or repair of oxidatively damaged nucleic acids.
• Enzymology Studies: Acts as a probe to study the specificity, kinetics, and fidelity of polymerases, nucleotidyltransferases, and other nucleotide-processing enzymes when presented with damaged substrates.
• Reference Standard: Used as an analytical standard for the precise quantification of 8-hydroxyguanosine and its derivatives in complex matrices for toxicology and metabolic studies.

Basic Information

Product Name	8-Hydroxyguanosine Triphosphate
CAS No.	21238-36-8
Molecular Formula	C10H16N5O15P3
Molecular Weight	539.16 g/mol
Synonyms	8-OH-GTP; 8-Oxo-7,8-dihydroguanosine 5'-triphosphate; 8-Oxo-dGTP; 8-Hydroxy-2'-deoxyguanosine 5'-triphosphate (common misnomer, often used interchangeably); Oxidized GTP; 8-oxo-GTP; Guanosine 5'-triphosphate, 8-hydroxy-; 8-Oxo-7,8-dihydro-2'-deoxyguanosine-5'-triphosphate (for deoxy form, often searched in context)
EINECS	Contact for details

Quality Control

Our 8-Hydroxyguanosine Triphosphate is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes rigorous analytical testing, including HPLC for purity assessment and identity confirmation via mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term stability, store under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (Karl Fischer)	≤ 3.0%
Solubility	Soluble in water, slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.