Description

Tetrahydroaldosterone 3 β-Glucosiduronic Acid is a key steroidal metabolite and reference standard of significant analytical importance. This compound is essential for researchers and quality control laboratories requiring precise calibration and validation in metabolic studies. It is primarily utilized in pharmaceutical research, clinical diagnostics, and endocrinology for the quantification and study of aldosterone metabolism and related hormonal pathways.

Application

• Pharmaceutical Reference Standard: Used for the calibration of analytical instruments (HPLC, LC-MS) in drug metabolism and pharmacokinetic (DMPK) studies.
• Clinical Diagnostics: Serves as a critical calibrant in assays for diagnosing and monitoring disorders related to the renin-angiotensin-aldosterone system (RAAS).
• Endocrinology Research: A vital tool for investigating the metabolic pathways, excretion profiles, and biological activity of mineralocorticoids.
• Biomarker Analysis: Employed in the development and validation of methods to detect and quantify steroidal biomarkers in biological fluids.
• Quality Control (QC): Essential for ensuring the accuracy and reliability of in-house testing methods within pharmaceutical and diagnostic manufacturing.
• Academic Research: Supports fundamental studies in steroid biochemistry, hormone action, and metabolic disease models.

Basic Information

Product Name	Tetrahydroaldosterone 3 β-Glucosiduronic Acid
CAS No.	20605-81-6
Molecular Formula	C27H42O11
Molecular Weight	542.62 g/mol
Synonyms	3α,5β-Tetrahydroaldosterone 3-glucuronide; 3α,5β-Tetrahydroaldosterone 3β-D-Glucopyranosiduronic Acid; TH-Aldo 3-G; Aldosterone metabolite 3-G; 18,11-Hemiacetal of 3α,21-dihydroxy-5β-pregnane-11,20-dione 3-glucuronide; 5β-Pregnane-3α,21-diol-11,20-dione 18,11-hemiacetal 3-glucuronide; Tetrahydroaldosterone glucuronide
EINECS	Contact for details

Quality Control

Our Tetrahydroaldosterone 3 β-Glucosiduronic Acid is produced and handled under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for reference materials. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0% (on dried basis)
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.