Description

Cotarnine Chloride is a quaternary ammonium salt derivative of the natural alkaloid cotarnine. This compound is valued for its role as a key chemical intermediate and reference standard in advanced pharmaceutical research and synthesis. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and fine chemical sectors for developing and analyzing specialized therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of specialized alkaloid-based pharmaceuticals and potential therapeutic agents.
• Chemical Reference Standard: Used as a high-purity standard in analytical laboratories for quality control, method validation, and identification via techniques like HPLC and mass spectrometry.
• Biochemical Research: Employed in pharmacological and biochemical studies to investigate the properties and activities of isoquinoline alkaloid derivatives.
• Fine Chemical Synthesis: Acts as a precursor for the preparation of more complex chemical entities in custom synthesis and process development.

Basic Information

Product Name	Cotarnine Chloride
CAS No.	20276-45-3
Molecular Formula	C12H14ClNO4
Molecular Weight	271.70 g/mol
Synonyms	Cotarnine hydrochloride; 6,7-Dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid methyl ester hydrochloride; Narcotine chloromethylate; Hydrocotarnine chloride; Stypticin (historical); Cotarninium chloride
EINECS	243-692-7

Quality Control

Our Cotarnine Chloride is produced and tested under a rigorous quality management system. Each batch undergoes comprehensive analysis to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided, documenting key parameters such as assay, related substances, and residual solvents. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.