Description

Homatropine Sulfate CAS NO 20223-46-5 is a quaternary ammonium salt derived from tropine, functioning as a competitive muscarinic acetylcholine receptor antagonist. This compound is valued for its reliable anticholinergic and mydriatic (pupil-dilating) properties, making it a critical active pharmaceutical ingredient (API) in ophthalmic preparations. It is primarily required by pharmaceutical manufacturers and compounding pharmacies for the formulation of diagnostic and therapeutic eye drops used in ocular examinations and treatments.

Application

• Ophthalmic Solutions: As the active ingredient in prescription eye drops for cycloplegic refraction (paralyzing eye accommodation) and mydriasis (pupil dilation) during diagnostic procedures.
• Pharmaceutical Intermediates: Serves as a key synthetic precursor or intermediate in the manufacture of more complex anticholinergic drugs.
• Research & Development: Used in biochemical and pharmacological research as a standard muscarinic receptor antagonist to study cholinergic pathways and receptor functions.
• Veterinary Medicine: Employed in veterinary ophthalmic practices for diagnostic eye examinations in animals.
• Compounding Pharmacy: Utilized by specialized pharmacies to prepare customized dosage forms for patients with specific needs not met by commercial products.

Basic Information

Product Name	Homatropine Sulfate
CAS No.	20223-46-5
Molecular Formula	C16H24N2O6S
Molecular Weight	396.44 g/mol
Synonyms	Homatropine Sulphate; Tropine Mandelate Sulfate; (1R,3r,5S)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 2-hydroxy-2-phenylacetate sulfate (2:1); DL-Homatropine Sulfate; Homatropini Sulfas; Mandelyltropine Sulfate
EINECS	243-634-9

Quality Control

Our Homatropine Sulfate is manufactured under strict quality management systems. It undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications, including identification, assay, impurity profiling, and residual solvent analysis. A Certificate of Analysis (COA) documenting compliance with relevant specifications is provided with each batch. We can supply material aligned with pharmacopeial standards such as USP or EP upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent absorption of atmospheric moisture, which can affect stability and potency.

Specification

Item	Specification
Appearance	White or almost white, crystalline powder
Identification (IR)	Conforms
Identification (Titration)	Conforms
Assay (HPLC)	98.0% - 102.0% (on dried basis)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.