Description

Z-Gly-Osu CAS NO 2899-60-7 is a high-purity, crystalline N-hydroxysuccinimide (NHS) ester derivative of Z-protected glycine, serving as a critical building block in peptide synthesis. This compound is essential for facilitating efficient and selective amide bond formation, particularly in solid-phase peptide synthesis (SPPS) and bioconjugation strategies. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers developing therapeutic peptides, diagnostic probes, and novel biomaterials.

Application

• Peptide Synthesis: A key reagent for the incorporation of Z-protected glycine residues during stepwise peptide chain elongation.
• Bioconjugation & Labeling: Used to covalently attach glycine-linked peptides, tags, or probes to amines on proteins, antibodies, or other biomolecules.
• Pharmaceutical Intermediate: Serves as a crucial intermediate in the synthesis of complex peptide-based active pharmaceutical ingredients (APIs).
• Research & Development: Employed in academic and industrial labs for exploring new synthetic methodologies and constructing peptide libraries.
• Prodrug Synthesis: Facilitates the creation of peptide prodrugs by enabling specific linkages designed for controlled release.
• Material Science: Used in the functionalization of surfaces and polymers with peptide motifs for biomedical applications.

Basic Information

Product Name	Z-Gly-Osu
CAS No.	2899-60-7
Molecular Formula	C14H16N2O6
Molecular Weight	308.29 g/mol
Synonyms	N-[(Benzyloxy)carbonyl]glycine N-hydroxysuccinimide ester; Z-Glycine N-succinimidyl ester; N-Cbz-Glycine N-hydroxysuccinimide ester; N-Carbobenzoxyglycine N-hydroxysuccinimide ester; N-Succinimidyl N-carbobenzoxyglycinate; Z-Gly-OSu; Z-Glycine-OSu; NSC 334681
EINECS	220-795-3

Quality Control

Every batch of Z-Gly-Osu is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay (HPLC), chiral purity, and residual solvent levels. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for critical research and production applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	118 - 122 °C
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.