Description

(2'S)-Nicotine 1-Oxide is a specific stereoisomer of nicotine N-oxide, a key metabolite and chemical intermediate. This compound is of significant interest for its role in advanced research and the development of analytical standards. It serves as a critical reference material for laboratories in the pharmaceutical and life science sectors requiring high-purity, well-characterized substances for method validation and metabolic studies.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and identification of nicotine metabolites in pharmacokinetic and toxicological studies.
• Metabolic Pathway Research: A vital intermediate for studying the in vivo and in vitro metabolic pathways of nicotine, aiding in the understanding of addiction mechanisms and drug interactions.
• Analytical Method Development: Serves as a high-purity calibrant in developing and validating sensitive analytical methods, such as LC-MS/MS and HPLC, for bioanalysis.
• Biochemical Research: Employed in enzymatic studies to investigate the activity of Flavin-containing monooxygenases (FMOs) responsible for N-oxidation.
• Impurity Profiling: Used as an impurity standard in the quality control of nicotine and related pharmaceutical compounds to ensure product safety and compliance.

Basic Information

Product Name	(2'S)-Nicotine 1-Oxide
CAS No.	2820-55-5
Molecular Formula	C10H14N2O
Molecular Weight	178.23 g/mol
Synonyms	(S)-Nicotine 1-Oxide; (S)-Nicotine N-Oxide; (-)-Nicotine 1-Oxide; (S)-(-)-Nicotine N-Oxide; 3-[(2S)-1-Methyl-2-pyrrolidinyl]pyridine 1-oxide; Nicotine N-Oxide (S-isomer); (2'S)-1'-Methyl-2'-(3-pyridyl)pyrrolidine 1-oxide
EINECS	220-588-8

Quality Control

Every batch of our (2'S)-Nicotine 1-Oxide is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and strength, meeting the exacting standards required for research and reference materials. A detailed Certificate of Analysis (COA) including results for assay, chiral purity, and related substances is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (2'S-isomer)
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.