Description

Thiocolchicine is a sulfur-containing derivative of the natural alkaloid colchicine, characterized by the replacement of a methoxy group with a methylthio group. This structural modification significantly alters its biological activity and physicochemical properties, making it a valuable intermediate for advanced pharmaceutical research and development. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel therapeutic agents and the study of tubulin-binding compounds. The compound is supplied under the identifier CAS NO 2730-71-4.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel colchicine analogs and potential chemotherapeutic agents.
• Biochemical Research: Used as a reference standard and tool compound in studies investigating tubulin polymerization inhibition and cytoskeleton dynamics.
• Medicinal Chemistry: A crucial starting material for structure-activity relationship (SAR) studies aimed at developing new anti-inflammatory and anti-gout medications.
• Academic Research: Employed in university and institutional labs for pharmacological and toxicological profiling of colchicinoid compounds.

Basic Information

Product Name	Thiocolchicine
CAS No.	2730-71-4
Molecular Formula	C22H25NO5S
Molecular Weight	415.50 g/mol
Synonyms	N-[(7S)-1,2,3,10-Tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide; Colchiceine Trimethyl Ether Thioacetate; 3-Demethylthiocolchicine; Thiocolchicine; Thiocolchicoside Aglycone; N-Acetyl-1,2,3-trimethoxy-9-thiocolchicone; 7-Acetamido-6,7-dihydro-1,2,3,10-tetramethoxy-benzo[a]heptalen-9(5H)-thione
EINECS	Contact for details

Quality Control

Our Thiocolchicine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets high-purity standards suitable for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.