Description

9-Fluoro-11,17,21-Trihydroxy-16-Methylpregna-1,4-Diene-3,20-Dione21-Phosphate Piperazine Salt is a high-purity, water-soluble phosphate ester salt derivative of a fluorinated corticosteroid, designed for enhanced stability and bioavailability in advanced pharmaceutical formulations. This compound is critical for researchers and manufacturers requiring a reliable, high-quality active pharmaceutical ingredient (API) intermediate for the development of potent anti-inflammatory and immunosuppressive therapies. It is primarily utilized in the synthesis of next-generation injectable and topical corticosteroid medications targeting severe dermatological, ophthalmic, and systemic inflammatory conditions.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potent corticosteroid APIs, such as dexamethasone phosphate derivatives.
• Injectable Formulations: Used in the development of sterile injectable solutions and suspensions for rapid systemic anti-inflammatory action.
• Ophthalmic Solutions: Serves as a precursor in medications for treating inflammatory eye diseases like uveitis and conjunctivitis.
• Topical Creams & Ointments: Intermediate for high-potency dermatological corticosteroids used in psoriasis, eczema, and dermatitis.
• Research & Development: Essential reference standard and starting material in pharmacological research for novel glucocorticoid receptor agonists.
• Veterinary Pharmaceuticals: Employed in the development of anti-inflammatory treatments for companion and livestock animals.

Basic Information

Product Name	9-Fluoro-11,17,21-Trihydroxy-16-Methylpregna-1,4-Diene-3,20-Dione21-Phosphate Piperazine Salt
CAS No.	2707-37-1
Molecular Formula	C26H37FN2O8P
Molecular Weight	564.56 g/mol
Synonyms	Dexamethasone 21-Phosphate Piperazine Salt; 9α-Fluoro-16α-methylprednisolone 21-phosphate piperazine salt; Dexamethasone Phosphate Piperazine Salt; Dexamethasone Sodium Phosphate Related Compound C (Piperazine Salt); 1,4-Diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methylpregna-, 21-(dihydrogen phosphate), compd. with piperazine (1:1); NSC-12363; Dexamethasone Phosphate Piperazine; Dexamethasone 21-(Dihydrogen Phosphate) Compound with Piperazine (1:1)
EINECS	Contact for details

Quality Control

Our 9-Fluoro-11,17,21-Trihydroxy-16-Methylpregna-1,4-Diene-3,20-Dione21-Phosphate Piperazine Salt is manufactured under strict quality systems suitable for pharmaceutical intermediate use. Each batch undergoes rigorous analytical testing including HPLC for purity, identification by IR and NMR, and control of specific impurities to ensure compliance with in-house specifications aligned with ICH guidelines. Certificates of Analysis (COA) detailing all test results are provided with every shipment to guarantee traceability and consistency for your critical R&D and cGMP manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 3.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.