Description

Diflorasone is a synthetic corticosteroid belonging to the dihalogenated androstane class, recognized for its potent anti-inflammatory and antipruritic properties. This high-purity active pharmaceutical ingredient (API) is critical for formulators requiring reliable efficacy and consistent quality in topical dermatological preparations. It is primarily utilized by pharmaceutical manufacturers and compounding pharmacies serving the global dermatology market.

Application

• Topical Corticosteroid Formulations: Core ingredient in creams, ointments, and lotions for treating inflammatory skin conditions.
• Dermatological Therapeutics: Used in prescription medications for psoriasis, eczema, contact dermatitis, and other corticosteroid-responsive dermatoses.
• Veterinary Medicine: Incorporated into topical treatments for managing skin inflammation and allergic reactions in animals.
• API for Compounding: Sourced by specialized pharmacies for custom-formulated dermatological preparations to meet specific patient needs.
• Clinical Research: Serves as a reference standard and active component in studies investigating new topical delivery systems or comparative efficacy.

Basic Information

Product Name	Diflorasone
CAS No.	2557-49-5
Molecular Formula	C22H28F2O5
Molecular Weight	410.45 g/mol
Synonyms	Diflorasone Diacetate; 6α,9α-Difluoro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17,21-diacetate; 6α,9α-Difluoro-16β-methylprednisolone 17,21-diacetate; Flucort; Dermalar; Maxiflor; Florone; NSC-112682
EINECS	219-864-7

Quality Control

Our Diflorasone is manufactured under strict quality management systems to ensure it meets the stringent requirements for pharmaceutical actives. Each batch is tested against comprehensive specifications, including identity, purity, and impurity profiles, utilizing validated analytical methods such as HPLC and IR spectroscopy. Certificates of Analysis (COA) documenting full compliance are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.