Description

Corticosterone-[1,2-3H(N)] CAS NO 2545-32-6 is a high-specific-activity, tritium-labeled derivative of corticosterone, a key glucocorticoid hormone. This radiolabeled compound is essential for high-sensitivity detection and quantification in advanced biochemical research. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and clinical diagnostic developers for metabolic studies, receptor binding assays, and tracer applications in endocrinology.

Application

• Receptor Binding & Competitive Assays: Used as a tracer to study glucocorticoid receptor (GR) affinity and function in vitro.
• Metabolic Pathway Tracing: Enables the detailed tracking and analysis of corticosterone metabolism and conversion pathways.
• Drug Discovery & Development: Serves as a critical tool for screening and evaluating novel steroid-based therapeutics and inhibitors.
• Biomedical Research: Facilitates studies on stress response, HPA axis regulation, and related physiological mechanisms.
• Analytical Method Development: Acts as a reference standard in the development and validation of sensitive LC-MS/MS or RIA methods.
• Clinical Diagnostics Research: Employed in research for developing assays to measure corticosterone levels in biological samples.

Basic Information

Product Name	Corticosterone-[1,2-3H(N)]
CAS No.	2545-32-6
Molecular Formula	C21H28O4 (³H-labeled)
Molecular Weight	~348.5 g/mol (unlabeled)
Synonyms	11β,21-Dihydroxypregn-4-ene-3,20-dione-[1,2-³H]; [1,2-³H]Corticosterone; Tritiated Corticosterone; 17-Deoxycortisol-[1,2-³H]; 4-Pregnene-11β,21-diol-3,20-dione-[1,2-³H]; Compound B-[1,2-³H]; 11β,21-Dihydroxyprogesterone-[1,2-³H]
EINECS	219-823-8 (for unlabeled corticosterone)

Quality Control

Every batch of Corticosterone-[1,2-3H(N)] is manufactured and analyzed under strict quality systems. We guarantee high radiochemical purity and specific activity, with comprehensive testing including HPLC and radio-HPLC analysis. A detailed Certificate of Analysis (COA), specifying activity, purity, solvent, and stability data, is provided with each shipment to ensure traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at or below -20°C. This product is hygroscopic (moisture-sensitive). For long-term stability, it is recommended to store the material under an inert atmosphere. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	Solution in ethanol or toluene (colorless to pale yellow)
Specific Activity	Contact for details (Typical range: 40-80 Ci/mmol)
Radiochemical Purity (HPLC)	≥ 97%
Chemical Purity (HPLC)	≥ 98%
Concentration	1.0 mCi/mL (Contact for other concentrations)
Solvent	Ethanol or Toluene (Specified per batch)
Identification (IR / NMR)	Conforms to structure

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.