Description

3',5'-Dibromofolic Acid is a brominated derivative of folic acid, a key compound in biochemical research and pharmaceutical development. This modified structure is primarily valued for its role as a versatile synthetic intermediate and a tool for studying enzyme inhibition and metabolic pathways. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require high-purity building blocks for drug discovery and advanced material synthesis.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, particularly those targeting folate-dependent enzymes.
• Biochemical Research: Used as a probe or inhibitor in enzymatic studies to investigate the mechanisms of dihydrofolate reductase (DHFR) and other folate-utilizing enzymes.
• Chemical Synthesis: Acts as a specialized building block for the preparation of more complex brominated heterocyclic compounds and labeled analogs.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation in pharmaceutical analysis.

Basic Information

Product Name	3',5'-Dibromofolic Acid
CAS No.	2536-53-0
Molecular Formula	C₁₉H₁₇Br₂N₇O₆
Molecular Weight	607.19 g/mol
Synonyms	N-[4-[[(2-Amino-3,5-dibromo-4-oxo-1,4-dihydro-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic Acid; 3',5'-Dibromopteroylglutamic Acid; 3,5-Dibromofolic Acid; NSC 52907; 2-[[4-[(2-Amino-3,5-dibromo-4-oxopteridin-6-yl)methylamino]benzoyl]amino]pentanedioic Acid
EINECS	Contact for details

Quality Control

Our 3',5'-Dibromofolic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment to prevent degradation. For long-term storage, consider conditions under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.