Description

3-Deoxy-D-Glucose is a synthetic glucose analog where the hydroxyl group at the C-3 position is replaced by hydrogen. This structural modification makes it a valuable tool compound and metabolic inhibitor, primarily targeting glycolysis. It is extensively utilized in biochemical and pharmaceutical research for studying glucose metabolism, cellular energy pathways, and as a potential therapeutic agent. Key industries that require this high-purity chemical include pharmaceutical R&D, academic research institutions, and biotechnology companies developing metabolic disorder treatments.

Application

• Glycolysis Inhibition Research: Used as a competitive inhibitor of hexokinase to study glucose metabolism and energy deprivation in cell cultures.
• Cancer Research: Investigated for its potential to inhibit tumor cell growth by disrupting ATP production in glycolytic-dependent cancer cells.
• Virology Studies: Employed in research on viral replication, as some viruses depend on host cell glycolysis; used to study compounds like SARS-CoV-2.
• Neurobiological Research: Applied in studies of brain ischemia and neuronal cell death mechanisms related to energy metabolism.
• Antifungal Agent Development: Serves as a reference standard and starting material in developing novel antifungal agents.
• Diagnostic Probe Development: Used in the synthesis of molecular probes for imaging and diagnosing metabolic activities.
• Biochemical Reagent: Acts as a critical reagent in enzyme assays and metabolic pathway analysis kits.
• Pharmaceutical Intermediate: Utilized as a chiral building block in the synthetic routes of more complex bioactive molecules.

Basic Information

Product Name	3-Deoxy-D-Glucose
CAS No.	2490-91-7
Molecular Formula	C6H12O5
Molecular Weight	164.16 g/mol
Synonyms	3-Deoxy-D-arabino-hexose; D-3-Deoxyglucose; 3-Deoxy-D-glucose; 3dDG; 3-DG; 3-Deoxyglucose; (2R,4S,5R)-2-(Hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
EINECS	219-656-8

Quality Control

Every batch of our 3-Deoxy-D-Glucose is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with each shipment, detailing parameters such as assay, optical rotation, and impurity profiles. Our standard grade meets the requirements for research use, and we can support development under cGMP guidelines for advanced pharmaceutical applications. Specifications are aligned with industry standards for high-purity biochemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed after each use to prevent absorption of atmospheric moisture, which can affect purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	-30° to -34° (c=1 in H2O)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.