Description

Estriol 3-Glucuronide is a major, water-soluble metabolite of the endogenous estrogen estriol, formed via glucuronidation. This compound is of significant value as a critical reference standard and biomarker in clinical and pharmaceutical research. It is essential for laboratories focused on hormone metabolism studies, diagnostic assay development, and pharmacokinetic research, providing a reliable benchmark for accurate quantification and method validation.

Application

• Biomarker and Diagnostic Reference Standard for quantifying estriol metabolites in clinical samples (e.g., urine, serum) to assess endocrine function and fetal health during pregnancy.
• Pharmacokinetic and Metabolism Studies in pharmaceutical R&D to understand the metabolic pathways, clearance, and bioavailability of estriol and related steroid therapeutics.
• Calibration and Quality Control material for analytical techniques such as LC-MS/MS, HPLC, and ELISA in clinical chemistry and bioanalytical laboratories.
• Enzymatic Activity Assays used to study the function and kinetics of UDP-glucuronosyltransferase (UGT) enzymes involved in phase II drug metabolism.
• Research into Endocrine Disrupting Chemicals (EDCs), serving as a control compound to investigate the effects of xenobiotics on estrogen metabolism and homeostasis.

Basic Information

Product Name	Estriol 3-Glucuronide
CAS No.	2479-91-6
Molecular Formula	C24H32O9
Molecular Weight	464.51 g/mol
Synonyms	Estriol 3-β-D-Glucuronide; Estr-5(10)-ene-3,16α,17β-triol 3-(β-D-glucopyranosiduronic acid); 16α-Hydroxyestriol 3-glucuronide; Estriol 3G; E3G; NSC 113233; 1,3,5(10)-Estratrien-3,16α,17β-triol 3-(β-D-glucopyranosiduronic acid)
EINECS	219-625-9

Quality Control

Our Estriol 3-Glucuronide is manufactured and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods and purity assessment by HPLC, to ensure it meets the high standards required for research and diagnostic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming batch-specific results for identity, purity, and related substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.