Description

1,2-Dihydro-1-Methyl-2β,16-(Epoxymethano)Akuammilan-17-Oic Acid Methyl Ester is a complex indole alkaloid derivative with a unique epoxymethano-bridged structure. This compound matters as a high-value pharmaceutical intermediate and a critical reference standard for research into bioactive natural products. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of fine chemicals for the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel alkaloid-based drug candidates.
• Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical and natural product analysis.
• Medicinal Chemistry Research: A crucial substrate for structure-activity relationship (SAR) studies to explore new bioactive compounds.
• Natural Product Synthesis: Employed in the total or semi-synthesis of complex akuammiline-type indole alkaloids.
• Biochemical Research: Used as a tool compound to investigate biological pathways and enzyme interactions related to its structural class.

Basic Information

Product Name	1,2-Dihydro-1-Methyl-2β,16-(Epoxymethano)Akuammilan-17-Oic Acid Methyl Ester
CAS No.	2447-70-3
Molecular Formula	C22H26N2O4
Molecular Weight	382.46 g/mol
Synonyms	Methyl (1R,2R,5S,7S,12bS,16S)-1-Methyl-2,16-epoxyakuammilan-17-oate; 16(S)-Epoxyakuammiline; 2,16-Epoxyakuammiline; 16-Epoxyakuammiline; Methyl 1,2-dihydro-1-methyl-2,16-epoxyakuammilan-17-oate; Akuammiline, 16,17-didehydro-16(S)-epoxy-; (1R,2R,5S,7S,12bS,16S)-1-Methyl-2,16-epoxyakuammilan-17-oic acid methyl ester
EINECS	Contact for details

Quality Control

Our 1,2-Dihydro-1-Methyl-2β,16-(Epoxymethano)Akuammilan-17-Oic Acid Methyl Ester is produced and handled under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS), to ensure it meets the high standards required for research and pharmaceutical applications. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.