Description

(5Alpha,17Beta)-17-Methylspiro[Androstane-3,3'-[3H]Diazirin]-17-Ol CAS NO 2429-17-6 is a specialized, high-purity steroid derivative featuring a diazirine photoaffinity label, making it a critical tool for advanced biochemical and pharmacological research. This compound's core value lies in its ability to act as a photoactivatable cross-linking agent, enabling the study of protein-ligand interactions, receptor mapping, and metabolic pathways with high precision. It is essential for research and development scientists in pharmaceutical discovery, endocrinology, and molecular biology who require reliable, high-quality probes for photolabeling experiments.

Application

• Photoaffinity Labeling Probes: Used as a critical reagent in photolabeling studies to covalently tag and identify biological targets such as steroid hormone receptors and binding proteins.
• Biochemical Research: Employed in the investigation of steroid metabolism pathways, enzyme mechanisms, and the structural analysis of protein-steroid complexes.
• Pharmaceutical R&D: Serves as a key intermediate or tool compound in the discovery and development of novel therapeutic agents targeting hormonal pathways.
• Metabolic Studies: Utilized as a tracer in metabolic studies due to its potential incorporation of tritium ([3H]), allowing for sensitive detection and quantification.
• Receptor Mapping: Applied in mapping the binding sites of androgen and other steroid receptors to understand ligand-receptor interactions at a molecular level.

Basic Information

Product Name	(5Alpha,17Beta)-17-Methylspiro[Androstane-3,3'-[3H]Diazirin]-17-Ol
CAS No.	2429-17-6
Molecular Formula	C₂₁H₃₂N₂O
Molecular Weight	328.50 g/mol
Synonyms	17-Methylspiro[androstane-3,3'-[3H]diazirin]-17-ol, (5α,17β)-; 17β-Hydroxy-17α-methylandrostano[3,2-c]diazirine; 17-Methylandrostano[3,2-c]diazirin-17-ol; Photoactivatable Androstane Derivative; Diazirine-labeled Steroid; Androstane Diazirinol; Spiro[diazirine-3,3'-androstan]-17-ol Derivative
EINECS	Contact for details

Quality Control

Our (5Alpha,17Beta)-17-Methylspiro[Androstane-3,3'-[3H]Diazirin]-17-Ol is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive research applications. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity, purity, and isotopic labeling where specified. Certificates of Analysis (COA) with detailed specifications are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Due to its light-sensitive and highly volatile nature, prolonged exposure to light, heat, or open air should be avoided to maintain stability and purity. For long-term storage, consider storing under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Specific Rotation	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.