Description

(11B)-11,17,21-Trihydroxy-3,20-Dioxo-Pregn-4-En-18-Al is a high-purity steroid derivative and a key synthetic intermediate in the pharmaceutical industry. Its precise molecular structure makes it a critical building block for the development of advanced corticosteroid and other steroidal APIs. This compound is essential for research institutions and manufacturers engaged in the synthesis of novel therapeutic agents, process development, and analytical reference standards. We supply this material with a focus on consistent quality and reliable global supply chain support.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of potent corticosteroid active pharmaceutical ingredients (APIs).
• Research & Development: Used in medicinal chemistry for the design, synthesis, and structure-activity relationship (SAR) studies of new steroidal compounds.
• Reference Standard: Serves as a high-purity analytical standard for quality control (QC) and method validation in pharmaceutical laboratories.
• Process Chemistry: Employed in route scouting and optimization for the commercial-scale manufacturing of steroid-based drugs.
• Biochemical Research: Utilized in studies investigating steroid hormone metabolism, receptor binding, and biological pathways.

Basic Information

Product Name	(11B)-11,17,21-Trihydroxy-3,20-Dioxo-Pregn-4-En-18-Al
CAS No.	2410-60-8
Molecular Formula	C21H28O6
Molecular Weight	376.45 g/mol
Synonyms	18-Aldehydocortisone; 18-Oxocortisone; 11β,17α,21-Trihydroxy-3,20-dioxopregn-4-en-18-al; 18-Formylcortisone; 18-Aldehyde Cortexone; Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, 18-aldehyde, (11β)-; Cortisone 18-aldehyde
EINECS	Contact for details

Quality Control

Our (11B)-11,17,21-Trihydroxy-3,20-Dioxo-Pregn-4-En-18-Al is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, IR, and other relevant pharmacopeial methods. Our quality commitment supports applications requiring GMP-grade intermediates and research materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.