Description

8-Br-GTP Sodium Salt is a chemically modified nucleotide analog where a bromine atom is substituted at the 8-position of the guanine base. This modification is crucial for its role as a potent and specific inhibitor of G-proteins and small GTPases in biochemical research. It is an essential tool compound for studying signal transduction pathways, enzyme kinetics, and cellular regulation mechanisms. Researchers in biochemistry, molecular pharmacology, and cell biology rely on this high-purity reagent for precise mechanistic studies.

Application

• Biochemical Research: Used as a non-hydrolyzable analog to study GTP-binding proteins (G-proteins) and GTPase enzymes.
• Signal Transduction Studies: Essential for investigating cellular signaling pathways involving Ras, Rho, and other small GTPases.
• Enzyme Inhibition Assays: Serves as a specific inhibitor in kinetic studies to determine enzyme mechanisms and affinities.
• Molecular Pharmacology: Employed in screening and characterizing compounds that target GTP-dependent processes.
• Cell Biology: Utilized in experiments to probe the role of GTPases in cytoskeleton dynamics, cell division, and vesicle transport.
• Diagnostic Development: Acts as a key component in developing assays for diseases linked to aberrant GTPase signaling.

Basic Information

Product Name	8-Br-GTP Sodium Salt
CAS No.	2397-98-0
Molecular Formula	C10H11BrN5Na3O14P3 (or similar salt form)
Molecular Weight	Contact for details
Synonyms	8-Bromoguanosine-5'-triphosphate sodium salt; 8-Bromo-GTP trisodium salt; Guanosine-5'-triphosphate, 8-bromo-, sodium salt; 8-Br-GTP; 8-Bromo-5'-GTP sodium; 8-Bromoguanosine triphosphate sodium salt
EINECS	Contact for details

Quality Control

Our 8-Br-GTP Sodium Salt is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment. We adhere to ISO 9001 quality management standards, and our processes are designed to meet the rigorous demands of the global research community.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the product to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water or buffer solution
Biological Activity	Inhibits GTPase activity as expected

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.