Description

5-Aza-2'-Deoxycytidine is a potent and specific nucleoside analog that functions as a DNA methyltransferase inhibitor. This compound is critical for epigenetic research and therapeutic development, enabling the study and modulation of gene expression patterns. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology, neurology, and developmental biology.

Application

• Epigenetics Research: A key reagent for studying DNA methylation dynamics, gene silencing, and cellular reprogramming.
• Oncology Research: Investigated for its potential to reactivate tumor suppressor genes silenced by hypermethylation in various cancer cell lines.
• Stem Cell Research: Used to induce epigenetic changes and enhance cellular plasticity in stem cell differentiation and dedifferentiation studies.
• Biochemical Assay Development: Serves as a standard or active component in assays for screening and characterizing DNMT (DNA methyltransferase) inhibitors.
• Pharmaceutical Intermediate: Employed in the synthesis and development of novel therapeutic agents targeting epigenetic pathways.
• Cell Culture & In Vitro Studies: Applied in cell-based models to investigate the effects of DNA demethylation on phenotype, proliferation, and apoptosis.

Basic Information

Product Name	5-Aza-2'-Deoxycytidine
CAS No.	2353-33-5
Molecular Formula	C8H12N4O4
Molecular Weight	228.21 g/mol
Synonyms	Decitabine; 5-Aza-dC; 5-Aza-CdR; NSC 127716; 4-Amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one; 5-Aza-2'-deoxycytidine; 2'-Deoxy-5-azacytidine
EINECS	Contact for details

Quality Control

Our 5-Aza-2'-Deoxycytidine is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant guidelines for research-grade biochemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Solubility	Soluble in DMSO, sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.