Description

6Alpha-Hydroxycortisol is a significant steroid metabolite and synthetic intermediate of notable interest in pharmaceutical research and development. Its primary value lies in its role as a key reference standard and precursor for the synthesis of more complex corticosteroid analogs and diagnostic markers. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors, particularly those focused on endocrine research, metabolic studies, and high-purity active pharmaceutical ingredient (API) production.

Application

• Pharmaceutical Reference Standard: Used as a high-purity calibrant in quantitative analytical methods such as HPLC and LC-MS for drug metabolism and pharmacokinetic (DMPK) studies.
• Biochemical Research: Serves as a critical reagent in investigating cortisol metabolism pathways, enzyme activity assays, and steroid hormone receptor studies.
• API Synthesis Intermediate: Acts as a key building block in the multi-step synthesis of novel corticosteroid derivatives and potential therapeutic agents.
• Diagnostic Development: Employed in the development and calibration of diagnostic kits and assays for measuring cortisol and related metabolites in clinical samples.
• Metabolite Identification: Used as an authentic standard to identify and characterize unknown steroid metabolites in complex biological matrices.

Basic Information

Product Name	6Alpha-Hydroxycortisol
CAS No.	2242-98-0
Molecular Formula	C21H30O6
Molecular Weight	378.46 g/mol
Synonyms	6α-Hydroxycortisol; 6α-Hydroxyhydrocortisone; 11β,17α,21-Trihydroxy-6α-pregn-4-ene-3,20-dione; (6α,11β)-11,17,21-Trihydroxypregn-4-ene-3,20-dione; 6α-OH-Cortisol; Cortisol 6α-ol
EINECS	Contact for details

Quality Control

Our 6Alpha-Hydroxycortisol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including identity confirmation by IR and NMR, purity assessment by HPLC, and specific tests for related substances and residual solvents. A Certificate of Analysis (COA) detailing all test results and specifications is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.