Description

(S)-(-)-Methylsuccinic Acid CAS NO 2174-58-5 is a high-purity, single-enantiomer chiral building block of significant importance in asymmetric synthesis. Its defined stereochemistry makes it a critical intermediate for producing optically active pharmaceuticals, agrochemicals, and advanced materials. This compound is essential for research and development chemists and production units in the pharmaceutical, fine chemical, and specialty chemical industries seeking to introduce specific chiral centers into complex molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in developing cardiovascular, neurological, and anti-inflammatory drugs.
• Asymmetric Catalyst Ligand Precursor: Used to construct chiral ligands for metal-catalyzed asymmetric reactions, enhancing enantioselectivity in industrial chemical processes.
• Fine Chemical Synthesis: Serves as a building block for fragrances, flavors, and other high-value specialty chemicals where optical purity is paramount.
• Agrochemical Research: Employed in the development of enantiomerically pure herbicides, pesticides, and plant growth regulators for improved efficacy and environmental profile.
• Polymer Modification: Used to introduce chiral centers into polymers, potentially modifying their physical properties for specialized material science applications.
• Biochemical Research: Acts as a standard or intermediate in metabolic pathway studies and enzyme substrate/ inhibitor research.

Basic Information

Product Name	(S)-(-)-Methylsuccinic Acid
CAS No.	2174-58-5
Molecular Formula	C5H8O4
Molecular Weight	132.11 g/mol
Synonyms	(S)-2-Methylbutanedioic Acid; (S)-(-)-Methylsuccinic Acid; (S)-Methylsuccinic Acid; L-Methylsuccinic Acid; (2S)-2-Methylbutanedioic Acid; (S)-1,2-Dimethylenesuccinic Acid; (S)-Pyrotartaric Acid
EINECS	218-536-6

Quality Control

Our (S)-(-)-Methylsuccinic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, assay, enantiomeric excess, and impurity profiles are provided and available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect product stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	110 - 115 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.